Estimation of the Secretion Rate of Thyrotropin in Man*

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Estimation of the secretion rate of thyrotropin in man.

The plasma concentration of a pituitary hormone is determined by the rate of secretion, degradation, and the volume of distribution of that hormone. Using a radioimmunoassay for human thyrotropin (TSH) and human TSH-(131)I, we have estimated the rates of degradation and distribution of TSH in man and calculated the rate of secretion. Either 0.5 or 5 mug of TSH-(131)I with specific activities of...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1967

ISSN: 0021-9738

DOI: 10.1172/jci105601